Prolotherapy is a relatively new method for treating chronic pain. It is based on the assumption that chronic pain in many cases involving numerous parts of the body is due to ligamentous laxity. Ligament laxity can be eliminated by strengthening the ligaments using prolotherapy injections made up of an irritating substances that stimulate connective tissue proliferation. The solutions are different mixtures that may contain phenol, glycerin, glucose hypertonic solution associated with local anesthetics. Prolotherapy injection treatment is very effective in association with physical therapy with the use of supplementation of minerals and vitamins.